BDBM50322422 CHEMBL1173445::Largazole

SMILES CCCCCCCC(=O)SCC\C=C\[C@@H]1CC(=O)NCc2nc(cs2)C2=N[C@@](C)(CS2)C(=O)N[C@@H](C(C)C)C(=O)O1

InChI Key InChIKey=AXESYCSCGBQJBL-SZPBEECKSA-N

Data  44 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50322422   

TargetHistone deacetylase 3(Homo sapiens (Human))
Chinese National Center For Drug Screening

Curated by ChEMBL
LigandPNGBDBM50322422(CHEMBL1173445 | Largazole)
Affinity DataIC50:  245nMAssay Description:Inhibition of recombinant human HDAC3 using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Chinese National Center For Drug Screening

Curated by ChEMBL
LigandPNGBDBM50322422(CHEMBL1173445 | Largazole)
Affinity DataIC50:  9.10nMAssay Description:Inhibition of recombinant full-length HDAC3 (unknown origin) using MAZ1600/MAZ1675 as substrate assessed as release of 7 amino-4-methylcoumarin measu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Chinese National Center For Drug Screening

Curated by ChEMBL
LigandPNGBDBM50322422(CHEMBL1173445 | Largazole)
Affinity DataIC50:  859nMAssay Description:Inhibition of recombinant human HDAC3 after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Chinese National Center For Drug Screening

Curated by ChEMBL
LigandPNGBDBM50322422(CHEMBL1173445 | Largazole)
Affinity DataIC50:  1.36E+3nMAssay Description:Inhibition of full length human recombinant KDAC3 using fluorophore-conjugated substrate measured as fluorigenic release of 7-amino-4-methylcoumarin ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Chinese National Center For Drug Screening

Curated by ChEMBL
LigandPNGBDBM50322422(CHEMBL1173445 | Largazole)
Affinity DataIC50:  670nMAssay Description:Inhibition of HDAC3 (unknown origin) using MAZ1600 and MAZ1675 as substrate assessed as fluorogenic release of 7-amino-4-methylcoumarin from substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Chinese National Center For Drug Screening

Curated by ChEMBL
LigandPNGBDBM50322422(CHEMBL1173445 | Largazole)
Affinity DataIC50:  604nMAssay Description:Inhibition of C-terminal His-tagged full length human recombinant HDAC3 co-expressed with NcoR2 in baculovirus expression system using fluorogenic ac...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Chinese National Center For Drug Screening

Curated by ChEMBL
LigandPNGBDBM50322422(CHEMBL1173445 | Largazole)
Affinity DataIC50:  50nMAssay Description:Inhibition of recombinant HDAC3 (unknown origin)incubated for 15 mins before substrate addition and measured after 30 to 45 mins by HDAC-Glo substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed